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Loss of Heterozygosity on Chromosome 5p13-12 Predicts Adverse Prognosis in Advanced Bladder Cancer Independent of Tumor Stage and Grade

✍ Scribed by BÖHM, MALTE; WIELAND, ILSE; SCHMIDT, CLAUS; RÜBBEN, HERBERT; ALLHOFF, ERNST PETER

Book ID
123070831
Publisher
Lippincott Williams and Wilkins
Year
2002
Tongue
English
Weight
614 KB
Volume
168
Category
Article
ISSN
0022-5347

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Loss of heterozygosity analysis on chrom
Loss of heterozygosity analysis on chromosome 5p defines 5p13-12 as the critical region involved in tumor progression of bladder carcinomas
✍ Malte Böhm; Rainer Kleine-Besten; Ilse Wieland 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 173 KB 👁 1 views

We have previously observed loss of heterozygosity (LOH) at a single locus (del-27) on human chromosome 5p13-12 to correlate with bladder tumor progression. In this study, we examined 33 bladder tumors for their pattern of allelic loss on chromosome 5p using 7 microsatellite markers. In 14 of 15 bla