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Hypermethylation and loss of heterozygosity of tumor suppressor genes on chromosome 3p in cervical cancer

✍ Scribed by Chel Hun Choi; Kyung-Mee Lee; Jung-Joo Choi; Tae-Joong Kim; Woo Young Kim; Jeong-Won Lee; Sun-Joo Lee; Je-Ho Lee; Duk-Soo Bae; Byoung-Gie Kim


Book ID
116334439
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
975 KB
Volume
255
Category
Article
ISSN
0304-3835

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## Abstract Loss of heterozygosity (LOH) at chromosome 3p21 is frequent in cervical cancers. The candidate tumor suppressor gene, __RASSF1A__ located at 3p21.3, is found to be inactivated in several major human cancers, implicating its significance in carcinogenesis. We aimed to investigate the sta