Frequent loss of heterozygosity on chromosome 10q in muscle-invasive transitional cell carcinomas of the bladder
✍ Scribed by Cappellen, David; Diez de Medina, Sixtina Gil; Chopin, Dominique; Thiery, Jean Paul; Radvanyi, François
- Book ID
- 110060763
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 446 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0950-9232
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Many tumors exhibit loss of heterozygosity (LOH) for polymorphic markers in regions of the genome that contain genes whose normal function can suppress tumor growth. Mapping of regions of LOH can help identify putative tumor suppressor loci that play a role in the pathogenesis of a disease. We evalu
The most frequent genetic aberration found in transitional cell carcinoma (TCC) of the bladder involves chromosome 9. Loss of heterozygosity (LOH) analyses show deletions of both chromosome 9p and 9q, while in situ hybridization studies suggest a significant percentage of tumours with monosomy 9. To