We have examined a series of 24 Merkel cell carcinoma (MCC) DNAs for loss of heterozygosity (LOH) at eight loci on chromosome 13. All patients were heterozygous for at least one locus. Overall, 18 of 24 (75%) patients showed LOH, among whom 10 patients demonstrated LOH at all informative loci. A sin
Loss of heterozygosity on chromosome 13 in squamous cell carcinomas of the larynx
β Scribed by Sujuan Bai; Xue Zhang; Jun Wang; Kailai Sun; Shengzhong Fei
- Publisher
- Chinese Anti-Cancer Association
- Year
- 1998
- Tongue
- English
- Weight
- 201 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1000-9604
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Background. Loss of heterozygosity (LOH) studies have been pivotal in identifying tumor suppressor genes involved in the pathogenesis of a number of cancers. In squamous cell carcinomas of the head and neck region (SCCHN), LOH studies using the Southern blot technique are scarce. Methods. SCCHNs we
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