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Frequent Occurrence of Loss of Heterozygosity among Tumor Suppressor Genes in Uterine Leiomyosarcoma

✍ Scribed by Ya-Li Zhai; Toshio Nikaido; Ayaka Orii; Akiko Horiuchi; Toshihiko Toki; Shingo Fujii

Book ID: 112247947
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 144 KB
Volume: 75
Category: Article
ISSN: 0090-8258
DOI: 10.1006/gyno.1999.5629

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## Abstract Loss of heterozygosity (LOH) at chromosome 3p21 is frequent in cervical cancers. The candidate tumor suppressor gene, __RASSF1A__ located at 3p21.3, is found to be inactivated in several major human cancers, implicating its significance in carcinogenesis. We aimed to investigate the sta