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Frequent loss of heterozygosity and altered expression of the candidate tumor suppressor gene 'FAT'in human astrocytic tumors

✍ Scribed by Kunzang Chosdol; Anjan Misra; Sachin Puri; Tapasya Srivastava; Parthaprasad Chattopadhyay; Chitra Sarkar; Ashok K Mahapatra; Subrata Sinha

Book ID: 115011796
Publisher: BioMed Central
Year: 2009
Tongue: English
Weight: 692 KB
Volume: 9
Category: Article
ISSN: 1471-2407
DOI: 10.1186/1471-2407-9-5

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## Abstract Loss of heterozygosity (LOH) at chromosome 3p21 is frequent in cervical cancers. The candidate tumor suppressor gene, __RASSF1A__ located at 3p21.3, is found to be inactivated in several major human cancers, implicating its significance in carcinogenesis. We aimed to investigate the sta