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Loss of Heterozygosity in the MXI1 Gene Is a Frequent Occurrence in Melanoma

โœ Scribed by Ariyanayagam-Baksh, S. M.


Book ID
110088449
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
155 KB
Volume
16
Category
Article
ISSN
0893-3952

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Commonly occurring loss and mutation of
โœ Edward V. Prochownik; Linette Eagle Grove; Debra Deubler; Xiao Lin Zhu; Robert A ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 341 KB ๐Ÿ‘ 2 views

One of the most common chromosomal abnormalities in prostate cancer involves loss of 10q22-qter. Rarely, a smaller deletion, involving 10q24-q25, has been observed, suggesting the presence of a tumor suppressor gene at this site. We previously demonstrated that the MXI1 gene maps to 10q24-q25 and is