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Frequency and nature of hMSH6 germline mutations in Polish patients with colorectal, endometrial and ovarian cancers

✍ Scribed by J Suchy; G Kurzawski; K Jakubowska; ME Rać; K Safranow; J Kładny; I Rzepka-Górska; M Chosia; B Czeszyńska; O Oszurek; RJ Scott; J Lubiński


Book ID
110888206
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
80 KB
Volume
70
Category
Article
ISSN
0009-9163

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Sequence analysis of the mismatch repair
✍ Jens Plaschke; Christian Kruppa; René Tischler; Tina Bocker; Steffen Pistorius; 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 634 KB

To evaluate the involvement of hMSH6 in colorectal cancer, the complete coding sequence and flanking intron regions of the gene were analyzed by DNA sequencing in 10 patients fulfilling Bethesda Guidelines for colorectal tumors and 10 patients with sporadic colorectal carcinoma. In addition, 10 mono