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Mutational Analysis of the hMSH6 Gene in Familial and Early-Onset Colorectal and Endometrial Cancer in Israeli Patients

✍ Scribed by Figer, Arie; Kaplan, Anna; Geva, Ravit; Flex, Dov; Yaron, Michal; Levy, Tali; Sapir, Einat Even; Fidder, Herma H.; Friedman, Eitan


Book ID
115489790
Publisher
Mary Ann Liebert
Year
2002
Tongue
English
Weight
101 KB
Volume
6
Category
Article
ISSN
1090-6576

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To evaluate the involvement of hMSH6 in colorectal cancer, the complete coding sequence and flanking intron regions of the gene were analyzed by DNA sequencing in 10 patients fulfilling Bethesda Guidelines for colorectal tumors and 10 patients with sporadic colorectal carcinoma. In addition, 10 mono