Genetic analysis of the APC gene regions involved in attenuated APC phenotype in Israeli patients with early onset and familial colorectal cancer
β Scribed by Figer, A.
- Book ID
- 111724591
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 53 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0007-0920
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Germline mutations in the tumor-suppresor APC gene are associated with hereditary familial adenomatous polyposis (FAP) and somatic mutations are common in sporadic colorectal cancer. In this study, we report the identification of three novel germline mutations: 1682-1683insA, 3252-3253insAT, 3544A>T
## Abstract A previously published modelβfree linkage analysis of chromosome 2q33β35, highlighted by previous caseβcontrol studies and supported by withinβfamily analyses employing the transmission disequilibrium test, revealed evidence of sexβspecific linkage of the __CREB1__βcontaining region of
Germline mutations within the adenomatous polyposis coli (APC) gene, a tumor suppressor gene, are responsible for most cases of familial adenomatous polyposis (FAP), an autosomal dominantly inherited predisposition to colorectal cancer. To date, more than 300 germ-line causative mutations within thi