Germline mutations in the tumor-suppresor APC gene are associated with hereditary familial adenomatous polyposis (FAP) and somatic mutations are common in sporadic colorectal cancer. In this study, we report the identification of three novel germline mutations: 1682-1683insA, 3252-3253insAT, 3544A>T
β¦ LIBER β¦
Molecular genetic analysis of exons 1 to 6 of the APC gene in non-polyposis familial colorectal cancer
β Scribed by Johanna A. Joyce; Nicola J. Froggatt; Rhodri Davies; D. Gareth R. Evans; Richard Trembath; David E. Barton; Eamonn R. Maher
- Book ID
- 115091755
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 569 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0009-9163
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## Communicated by Victor A. McKusick Germline mutations of the adenomatous polyposis cold (APC) gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominant predisposition to colorectal cancer. We screened the entire coding region of the APC gene for mutations in an unsele
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