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Germline mutations of hMLH1 and hMSH2 genes in patients with suspected hereditary nonpolyposis colorectal cancer and sporadic early-onset colorectal cancer

✍ Scribed by Ying Yuan; Hye-Jung Han; Shu Zheng; Jae-Gahb Park


Publisher
Springer
Year
1998
Tongue
English
Weight
881 KB
Volume
41
Category
Article
ISSN
0012-3706

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Mutation of the hMSH2 gene in two famili
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Communicated by Sauiu L.C. Woo We examined 18 unrelated individuals who have colorectal cancer or cancers associated with the HNPCC syndrome and have a family history of cancer for mutations in exon 13 of the hMSH2 gene. Two of the 18 individuals had the same previously unreported single-base delet