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Four novel germline mutations in theMLH1andPMS2mismatch repair genes in patients with hereditary nonpolyposis colorectal cancer

✍ Scribed by Mahdi Montazer Haghighi; Ramin Radpour; Katayoun Aghajani; Narges Zali; Mahsa Molaei; Mohammad Reza Zali

Publisher: Springer
Year: 2009
Tongue: English
Weight: 694 KB
Volume: 24
Category: Article
ISSN: 0179-1958
DOI: 10.1007/s00384-009-0731-1

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Worldwide, the DNA mismatch repair genes MSH2 and MLH1 account for a major share and almost equal proportions of hereditary nonpolyposis colorectal cancer (HNPCC). Furthermore, the predisposing mutation usually varies from kindred to kindred. In this study, we screened 29 verified or putative HNPCC