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Novel germline mutations ofhMSH2in a patient with hereditary nonpolyposis colorectal cancer (HNPCC) and in a patient with six primary cancers

✍ Scribed by S. Okamura; K. Koyama; Yasuo Miyoshi; Morito Monden; Motohisa Takami

Publisher: Nature Publishing Group
Year: 1998
Tongue: English
Weight: 207 KB
Volume: 43
Category: Article
ISSN: 1435-232X
DOI: 10.1007/s100380050057

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## Abstract Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal disorder caused by mutations in DNA mismatch repair (MMR) genes. Tumors of the HNPCC‐spectrum are associated with microsatellite instability (MSI) and loss of MMR protein expression. Lymphomas are not considered to be HNP