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Prevalence of germline mutations of hMLH1, hMSH2, hPMS1, hPMS2, and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal cancer

โœ Scribed by Q. Wang; C. Lasset; F. Desseigne; J.-C. Saurin; C. Maugard; C. Navarro; E. Ruano; L. Descos; V. Trillet-Lenoir; J.-F. Bosset; A. Puisieux


Publisher
Springer
Year
1999
Tongue
English
Weight
83 KB
Volume
105
Category
Article
ISSN
0340-6717

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Germ line mutations of hMSH2 and hMLH1 g
โœ M. Miyaki; M. Konishi; M. Muraoka; R. Kikuchi-Yanoshita; K. Tanaka; T. Iwama; T. ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Springer ๐ŸŒ English โš– 848 KB

Mutations in hMSH2 and hMLH1 genes were analyzed in patients from 11 Japanese families that had been diagnosed as carrying hereditary nonpolyposis colorectal cancer (HNPCC) by clinical examination. Germ line mutations of hMSH2 gene were identified in 5 independent families in which colorectal (87% o