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Relative frequency and morphology of cancers in carriers of germline TP53 mutations

✍ Scribed by Birch, Jillian M; Alston, Robert D; McNally, Richard JQ; Evans, D Gareth R; Kelsey, Anna M; Harris, Martin; Eden, Osborn B; Varley, Jennifer M


Book ID
110064881
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
174 KB
Volume
20
Category
Article
ISSN
0950-9232

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Using different molecular techniques, DNA has been shown to be present in plasma of patients with several types of tumors. Mutations of TP53 are the most common genetic changes in human cancers. We investigated the presence of TP53 gene mutations in plasma DNA of breast and small cell lung cancer pa