Relative frequency and morphology of cancers in carriers of germline TP53 mutations
β Scribed by Birch, Jillian M; Alston, Robert D; McNally, Richard JQ; Evans, D Gareth R; Kelsey, Anna M; Harris, Martin; Eden, Osborn B; Varley, Jennifer M
- Book ID
- 110064881
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 174 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0950-9232
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Mutations in the TP53 gene are considered to be among the most common genetic alterations in human cancers. Both somatic and germline mutations have been found. Using polymerase chain reaction (PCR). constant denaturant gel electrophoresis (CDGE), and denaturing gradient gel electrophoresis (DGGE),
Using different molecular techniques, DNA has been shown to be present in plasma of patients with several types of tumors. Mutations of TP53 are the most common genetic changes in human cancers. We investigated the presence of TP53 gene mutations in plasma DNA of breast and small cell lung cancer pa