Sarcomas in TP53 germline mutation carriers : A review of the IARC TP53 database
β Scribed by Simona Ognjanovic; Magali Olivier; Tracy L. Bergemann; Pierre Hainaut
- Book ID
- 102807028
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 1004 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0008-543X
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π SIMILAR VOLUMES
The tumor suppressor gene TP53 is frequently mutated in human cancers. More than 75% of all mutations are missense substitutions that have been extensively analyzed in various yeast and human cell assays. The International Agency for Research on Cancer (IARC) TP53 database (www-p53.iarc.fr) compiles
## Communicated by A. Jamie Cuticchia TP53 alteration is the most frequent genetic alteration found in human cancers. To date, more than 15,000 tumors with TP53 mutations have been published, leading to the description of more than 1,500 different TP53 mutants (http://p53.curie.fr). The frequency o
Communicated by Richard G.H. Cotton Mutations in the tumor suppressor gene TP53 are frequent in most human cancers. Comparison of the mutation patterns in different cancers may reveal clues on the natural history of the disease. Over the past 10 years, several databases of TP53 mutations have been d
Background. Secondary leukemia and myelodysplastic syndromes have been reported in patients following treatment for a wide range of neoplastic disorders. However, second malignancies after chemotherapy and/or irradiation for osteosarcoma are unusual. Procedure. We report the case of a 15-yearold gi
## Abstract ## BACKGROUND. A decrease in the age at cancer onset and increase in cancer incidence in successive generations in LiβFraumeni syndrome (LFS) families with germline __TP53__ mutations have been previously described. In the current study a possible relation was analyzed between telomere