A new way of constructing anomeric glycosyl phosphodiester linkages has been explored. Non-anomeric monosaccharide hydrogen phosphonate monoesters (5 and 9) have been used as acceptors in couplings using various benzylated galactosyl donors (trichloroacetimidate, thioglycoside, bromo and chloro sug
Formation of phosphodiester linkages by oxidation of a phosphoramidate
β Scribed by Eiko Ohtsuka; Shigeo Morioka; Morio Ikehara
- Publisher
- Elsevier Science
- Year
- 1972
- Tongue
- French
- Weight
- 151 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
The effects of the introduction of 2',5'-phosphodiester linkages within a hammerhead ribozyme domain have been examined in order to determine the regions which can be modified without impairing the cleavage activity and whether a substrate analogue, containing a 2',5'-linkage at the scissile positio
Activation of nucleoside 3' -hydrogenphosphonodithioates with iodine in the presence of nucleosides and amines yields dinucleoside phosphorodithioates and nucleoside phosphorodithioamidates, respectively. Similar activation of nucleoside 3' -methylphosphonothioates yields dinucleoside methylphosphon
A nucleoside dimer in which the natural phosphodiester bond is replaced by an isosteric amide linkage has been prepared. This dimer analogue was subsequently incorporated chemically at the cleavage position of a hammerhead ribozyme substrate. Although the resulting substrate analogue
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