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Cleavage activity of a hammerhead ribozyme domaincontaining 2′,5′-phosphodiester linkages

✍ Scribed by Fabienne Burlina; Jean-Louis Fourrey; Valérie Lefort; Alain Favre

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
317 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

The effects of the introduction of 2',5'-phosphodiester linkages within a hammerhead ribozyme domain have been examined in order to determine the regions which can be modified without impairing the cleavage activity and whether a substrate analogue, containing a 2',5'-linkage at the scissile position, could be cleaved.

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