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ChemInform Abstract: Replacement of the Cleavable Phosphodiester Bond of a Hammerhead Ribozyme Substrate by an Amide Linkage.

✍ Scribed by Fabienne Burlina; Alain Favre; Jean-Louis Fourrey; Martial Thomas


Publisher
John Wiley and Sons
Year
2010
Weight
24 KB
Volume
31
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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Replacement of the Cleavable Phosphodies
✍ Fabienne Burlina; Alain Favre; Jean-Louis Fourrey; Martial Thomas πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 324 KB

A nucleoside dimer in which the natural phosphodiester bond is replaced by an isosteric amide linkage has been prepared. This dimer analogue was subsequently incorporated chemically at the cleavage position of a hammerhead ribozyme substrate. Although the resulting substrate analogue