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Replacement of the Cleavable Phosphodiester Bond of a Hammerhead Ribozyme Substrate by an Amide Linkage

✍ Scribed by Fabienne Burlina; Alain Favre; Jean-Louis Fourrey; Martial Thomas

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 324 KB
Volume: 2000
Category: Article
ISSN: 1434-193X
DOI: 10.1002/(sici)1099-0690(200002)2000:4<633::aid-ejoc633>3.0.co;2-u

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✦ Synopsis

A nucleoside dimer in which the natural phosphodiester bond is replaced by an isosteric amide linkage has been prepared. This dimer analogue was subsequently incorporated chemically at the cleavage position of a hammerhead ribozyme substrate. Although the resulting substrate analogue

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ChemInform Abstract: Replacement of the

ChemInform Abstract: Replacement of the Cleavable Phosphodiester Bond of a Hammerhead Ribozyme Substrate by an Amide Linkage.

✍ Fabienne Burlina; Alain Favre; Jean-Louis Fourrey; Martial Thomas 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 24 KB

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