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Familial and sporadic Parkinson's disease usually display the same clinical features

✍ Scribed by J Carr; R de la Fuente-Fernández; M Schulzer; E Mak; S.M Calne; D.B Calne


Book ID
117751826
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
70 KB
Volume
9
Category
Article
ISSN
1353-8020

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✍ Ted M. Dawson; Valina L. Dawson 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 122 KB 👁 1 views

## Abstract Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic