Clinical Features of Sporadic and Familial Alzheimer's Disease
β Scribed by M.N. Rossor; N.C. Fox; P.A. Freeborough; R.J. Harvey
- Book ID
- 118769262
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 47 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1055-8330
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## Abstract ## Background Familial factors are clearly associated with an increased risk of developing late onset Alzheimer's disease (LOAD). However, there is emerging evidence to suggest that familial factors may also influence clinical phenotype. To date, most studies have focussed on familial
To resolve conflicting findings on the association of complement allotypes with Alzheimer's disease (AD) we have studied the C4 phenotypes in 33 sporadic cases and in one family with familial AD. We found no association with complement alleles in familial or sporadic AD, even though a familial case