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Clinical and Neuroimaging Features of Familial Alzheimer's Disease

✍ Scribed by M.N. ROSSOR; A.M. KENNEDY; R.S.J. FRACKOWIAK


Book ID
119873345
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
810 KB
Volume
777
Category
Article
ISSN
0890-6564

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Early onset familial Alzheimer's disease (AD) has an autosomal dominant mode of inheritance. T w o genes are responsible for the majority of cases of this subtype of AD. Mutations in the P-amyloid precursor protein (PAPP) gene on chromosome 21 have been shown to completely cosegregate with the disea