Clinical features of early onset, famili
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Mullan, Michael ;Bennett, Craig ;Figueredo, Cecilia ;Hughes, David ;Mant, Rebecc
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Article
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1995
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John Wiley and Sons
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English
⚖ 868 KB
Early onset familial Alzheimer's disease (AD) has an autosomal dominant mode of inheritance. T w o genes are responsible for the majority of cases of this subtype of AD. Mutations in the P-amyloid precursor protein (PAPP) gene on chromosome 21 have been shown to completely cosegregate with the disea