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Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease

✍ Scribed by Juliana Bronzova; Cornelia M. Duijn; Louis M. Havekes; Peter Knijff; Christine Broeckhoven; Albert Hofman

Publisher
Springer
Year
1996
Tongue
English
Weight
405 KB
Volume
243
Category
Article
ISSN
0340-5354

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## Abstract The effect of the apolipoprotein E (APOE) Ο΅4 allele on age of onset was analyzed in two groups of families with early‐onset Alzheimer's disease (AD), (1) Volga German (VG) kindreds, in which AD is caused by an unknown locus and (2) early‐onset non‐VG families showing evidence of linkage

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Early onset familial Alzheimer's disease (AD) has an autosomal dominant mode of inheritance. T w o genes are responsible for the majority of cases of this subtype of AD. Mutations in the P-amyloid precursor protein (PAPP) gene on chromosome 21 have been shown to completely cosegregate with the disea