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Apolipoprotein E genotypes and age of onset in early-onset familial Alzheimer's disease

✍ Scribed by Ephrat Levy-Lahad; Amnon Lahad; Ellen M. Wijsman; Thomas D. Bird; Dr Gerard D. Schellenberg

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
339 KB
Volume
38
Category
Article
ISSN
0364-5134

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✦ Synopsis

Abstract

The effect of the apolipoprotein E (APOE) Ο΅4 allele on age of onset was analyzed in two groups of families with early‐onset Alzheimer's disease (AD), (1) Volga German (VG) kindreds, in which AD is caused by an unknown locus and (2) early‐onset non‐VG families showing evidence of linkage to chromosome 14. The Ο΅4 allele did not have a detectable effect on age of onset in either group. This finding suggests some forms of early‐onset familial AD are not modifiable by APOE status, or that AD can be caused by APOE‐independent pathways.

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The apolipoprotein E (ApoE) genotype is a significant risk factor and modulator of age of onset of Alzheimer's disease (AD). We analyzed the effect of the ApoE genotype in two distinct early-onset familial AD groups: families with a mutation in the presenilin-1 gene (PS-1) on chromosome 14, and fami