Evidence for three loci modifying age-at-onset of Alzheimer's disease in early-onset PSEN2 families
β Scribed by Elizabeth E. Marchani; Thomas D. Bird; Ellen J. Steinbart; Elisabeth Rosenthal; Chang-En Yu; Gerard D. Schellenberg; Ellen M. Wijsman
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 274 KB
- Volume
- 9999B
- Category
- Article
- ISSN
- 1552-4841
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## Abstract The effect of the apolipoprotein E (APOE) Ο΅4 allele on age of onset was analyzed in two groups of families with earlyβonset Alzheimer's disease (AD), (1) Volga German (VG) kindreds, in which AD is caused by an unknown locus and (2) earlyβonset nonβVG families showing evidence of linkage
## Abstract We performed linkage analysis for age at onset (AAO) in the total Alzheimer's disease (AD) NIMH sample (Nβ=β437 families). Families were subset as lateβonset (320 families, AAO β₯65) and early/mixed (117 families, at least 1 member with 50< AAO <65). Treating AAO as a censored trait, we