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Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease

✍ Scribed by Peter Holmans; Marian Hamshere; Paul Hollingworth; Frances Rice; Nigel Tunstall; Sue Jones; Pamela Moore; Fabienne Wavrant DeVrieze; Amanda Myers; Richard Crook; Danielle Compton; Helen Marshall; David Meyer; Shantia Shears; Jeremy Booth; Dzanan Ramic; Nigel Williams; Nadine Norton; Richard Abraham; Pat Kehoe; Hywel Williams; Varuni Rudrasingham; Mick O'Donovan; Lesley Jones; John Hardy; Alison Goate; Simon Lovestone; Michael Owen; Julie Williams


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
191 KB
Volume
135B
Category
Article
ISSN
1552-4841

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## Abstract We performed linkage analysis for age at onset (AAO) in the total Alzheimer's disease (AD) NIMH sample (N = 437 families). Families were subset as late‐onset (320 families, AAO β‰₯65) and early/mixed (117 families, at least 1 member with 50< AAO <65). Treating AAO as a censored trait, we