Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease
β Scribed by Peter Holmans; Marian Hamshere; Paul Hollingworth; Frances Rice; Nigel Tunstall; Sue Jones; Pamela Moore; Fabienne Wavrant DeVrieze; Amanda Myers; Richard Crook; Danielle Compton; Helen Marshall; David Meyer; Shantia Shears; Jeremy Booth; Dzanan Ramic; Nigel Williams; Nadine Norton; Richard Abraham; Pat Kehoe; Hywel Williams; Varuni Rudrasingham; Mick O'Donovan; Lesley Jones; John Hardy; Alison Goate; Simon Lovestone; Michael Owen; Julie Williams
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 191 KB
- Volume
- 135B
- Category
- Article
- ISSN
- 1552-4841
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## Abstract We performed linkage analysis for age at onset (AAO) in the total Alzheimer's disease (AD) NIMH sample (Nβ=β437 families). Families were subset as lateβonset (320 families, AAO β₯65) and early/mixed (117 families, at least 1 member with 50< AAO <65). Treating AAO as a censored trait, we