## Abstract The effect of the apolipoprotein E (APOE) Ο΅4 allele on age of onset was analyzed in two groups of families with earlyβonset Alzheimer's disease (AD), (1) Volga German (VG) kindreds, in which AD is caused by an unknown locus and (2) earlyβonset nonβVG families showing evidence of linkage
Age of onset in familial early onset Alzheimer's disease correlates with genetic aetiology
β Scribed by Mullan, Michael ;Houlden, Henry ;Crawford, Fiona ;Kennedy, Angus ;Rogues, Penelope ;Rossor, Martin
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 183 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0148-7299
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The apolipoprotein E (ApoE) genotype is a significant risk factor and modulator of age of onset of Alzheimer's disease (AD). We analyzed the effect of the ApoE genotype in two distinct early-onset familial AD groups: families with a mutation in the presenilin-1 gene (PS-1) on chromosome 14, and fami