Familial and sporadic Alzheimer's disease: A clinical longitudinal study
โ Scribed by Giuseppina Talarico; Giuseppe Tosto; Elisa Piacentini; Marco Canevelli; Marco Pignatelli; Paola Piscopo; Alessio Crestini; Lorenzo Malvezzi Careggi; Annamaria Confaloni; Marina Gasparini; Manuela Salati; Gian Luigi Lenzi; Nicola Vanacore; Giuseppe Bruno
- Book ID
- 118464699
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 48 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1552-5260
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## Abstract ## Background Familial factors are clearly associated with an increased risk of developing late onset Alzheimer's disease (LOAD). However, there is emerging evidence to suggest that familial factors may also influence clinical phenotype. To date, most studies have focussed on familial
To resolve conflicting findings on the association of complement allotypes with Alzheimer's disease (AD) we have studied the C4 phenotypes in 33 sporadic cases and in one family with familial AD. We found no association with complement alleles in familial or sporadic AD, even though a familial case