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Complement allotypes in familial and sporadic alzheimer's disease

✍ Scribed by Peter K. Panegyres; Roger L. Dawkins

Publisher: Springer
Year: 1991
Tongue: English
Weight: 173 KB
Volume: 238
Category: Article
ISSN: 0340-5354
DOI: 10.1007/bf00315331

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✦ Synopsis

To resolve conflicting findings on the association of complement allotypes with Alzheimer's disease (AD) we have studied the C4 phenotypes in 33 sporadic cases and in one family with familial AD. We found no association with complement alleles in familial or sporadic AD, even though a familial case had absence of the C4 null allele (C4BQ0). Our data do not suggest a role for complement genes in the pathogenesis of AD. It also seems that the C4B2 allele cannot be used as a marker for AD as has been suggested by others.

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