Facile Synthesis of 1-Substituted 2-Amino-3-cyanopyrroles: New Synthetic Precursors for 5,6-Unsubstituted Pyrrolo[2,3- d ]pyrimidines
β Scribed by Chien, Tun-Cheng; Meade, Eric A.; Hinkley, Jack M.; Townsend, Leroy B.
- Book ID
- 120303055
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 54 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1523-7060
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## Abstract Some fluoroaryl substituted 2βaminoβ3βcyanopyrroles 2 were synthesized from the reaction between (2βbromoβ1βarylalkylidene)propanedinitriles 1 and fluoroaryl substituted aromatic amines under Gewald reaction condition, which on reaction with formamide and formic acid gave 4βaminopyrrolo
We have developed a new methodology for the construction of 5-substituted pyrrolo [2,3-d]pyrimidines that involves the reduction of a nitroalkane to an oxime using the reducing ability of the Sn(SR 3 ) -species, followed by mild, acid-catalysed deoximation of the resulting adduct using Dowex-H + res
The synthesis of 2,4-dimethoxypyrrolo[3,2-dlpyrimidine (4) is describe. d This facile, 3-step synthesis involves the brom&ation of 2,4zdimethoxy-6-methyl-5-nitropyrimidine (1) , and the subsequent conversion of compound 1 into compound 4.