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A novel method for the synthesis of 6,7-unsubstituted pyrrolo[3,2-d]pyrimidines

✍ Scribed by Thomas L. Cupps; Dean S. Wise; Leroy B. Townsend

Book ID: 104219716
Publisher: Elsevier Science
Year: 1982
Tongue: French
Weight: 157 KB
Volume: 23
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)85706-8

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✦ Synopsis

The synthesis of 2,4-dimethoxypyrrolo[3,2-dlpyrimidine (4) is describe. d

This facile, 3-step synthesis involves the brom&ation of 2,4zdimethoxy-6-methyl-5-nitropyrimidine (1) , and the subsequent conversion of compound 1 into compound 4.

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1,3-Dihydro-2H-indol-2-ones (oxindoles) and 1,3-dihydro-2H-pyrrolopyridin-2-ones (azaoxindoles) are useful scaffolds that have been explored for various pharmaceutical uses. Herein we report the synthesis of 2-chloro-5,7-dihydro-6H-pyrrolo [2,3d]pyrimidin-6-one (5) and its derivatives, and the appli