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Synthesis of Classical, Four-Carbon Bridged 5-Substituted Furo[2,3- d ]pyrimidine and 6-Substituted Pyrrolo[2,3- d ]pyrimidine Analogues as Antifolates 1

✍ Scribed by Gangjee, Aleem; Zeng, Yibin; McGuire, John J.; Kisliuk, Roy L.

Book ID: 120710665
Publisher: American Chemical Society
Year: 2005
Tongue: English
Weight: 124 KB
Volume: 48
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm058213s

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📜 SIMILAR VOLUMES

Synthesis of Classical, Three-Carbon-Bri

Synthesis of Classical, Three-Carbon-Bridged 5-Substituted Furo[2,3- d ]pyrimidine and 6-Substituted Pyrrolo[2,3- d ]pyrimidine Analogues as Antifolates 1

✍ Gangjee, Aleem; Zeng, Yibin; McGuire, John J.; Mehraein, Farideh; Kisliuk, Roy L 📂 Article 📅 2004 🏛 American Chemical Society 🌐 English ⚖ 148 KB

Synthesis, Antifolate, and Antitumor Act

Synthesis, Antifolate, and Antitumor Activities of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-pyrrolo[2,3- d ]pyrimidines

✍ Gangjee, Aleem; Vidwans, Anup; Elzein, Elfatih; McGuire, John J.; Queener, Sherr 📂 Article 📅 2001 🏛 American Chemical Society 🌐 English ⚖ 117 KB

Synthesis of Classical and a Nonclassica

Synthesis of Classical and a Nonclassical 2-Amino-4-oxo-6-methyl-5-substituted Pyrrolo[2,3- d ]pyrimidine Antifolate Inhibitors of Thymidylate Synthase 1

✍ Gangjee, Aleem; Mavandadi, Farahnaz; Kisliuk, Roy L.; Queener, Sherry F. 📂 Article 📅 1999 🏛 American Chemical Society 🌐 English ⚖ 100 KB

2-Amino-4-oxo-5-substituted-pyrrolo[2,3-

2-Amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines as Nonclassical Antifolate Inhibitors of Thymidylate Synthase

✍ Gangjee, Aleem; Mavandadi, Farahnaz; Kisliuk, Roy L.; McGuire, John J.; Queener, 📂 Article 📅 1997 🏛 American Chemical Society 🌐 English ⚖ 8 KB

ChemInform Abstract: Synthesis, Antifola

ChemInform Abstract: Synthesis, Antifolate, and Antitumor Activities of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines.

✍ Alleem Gangjee; Anup Vidwans; Elfatih Elzein; John J. McGuire; Sherry F. Queener 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB 👁 2 views

A new and versatile synthesis of 5-subst

A new and versatile synthesis of 5-substituted pyrrolo[2,3-d]pyrimidines

✍ Dolorès Edmont; David M Williams 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 80 KB

We have developed a new methodology for the construction of 5-substituted pyrrolo [2,3-d]pyrimidines that involves the reduction of a nitroalkane to an oxime using the reducing ability of the Sn(SR 3 ) -species, followed by mild, acid-catalysed deoximation of the resulting adduct using Dowex-H + res