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2-Amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines as Nonclassical Antifolate Inhibitors of Thymidylate Synthase

โœ Scribed by Gangjee, Aleem; Mavandadi, Farahnaz; Kisliuk, Roy L.; McGuire, John J.; Queener, Sherry F.


Book ID
126808726
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
8 KB
Volume
40
Category
Article
ISSN
0022-2623

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2-amino-4-oxo-6-substituted-pyrrolo[2,3-
โœ Aleem Gangjee; Jianming Yu; Roy L. Kisliuk ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 94 KB

## Abstract Classical, antifolate inhibitors of thymidylate synthase often suffer from a number of potential disadvantages when used as antitumor agents. These include impaired uptake due to an alteration of the active transport system required for cellular uptake, as well as the formation of long