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A new and versatile synthesis of 5-substituted pyrrolo[2,3-d]pyrimidines

✍ Scribed by Dolorès Edmont; David M Williams

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
80 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

We have developed a new methodology for the construction of 5-substituted pyrrolo [2,3-d]pyrimidines that involves the reduction of a nitroalkane to an oxime using the reducing ability of the Sn(SR 3 ) -species, followed by mild, acid-catalysed deoximation of the resulting adduct using Dowex-H + resin to form an intermediate aldehyde that spontaneously cyclises to the fused pyrrole ring.

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