✦ LIBER ✦

Synthesis and reactions of fluoroaryl substituted 2-amino-3-cyanopyrroles and pyrrolo[2,3-d]pyrimidines

✍ Scribed by Chaitanya G. Dave; Nirmal D. Desai

Publisher: Journal of Heterocyclic Chemistry
Year: 1999
Tongue: English
Weight: 272 KB
Volume: 36
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570360325

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✦ Synopsis

Abstract

Some fluoroaryl substituted 2‐amino‐3‐cyanopyrroles 2 were synthesized from the reaction between (2‐bromo‐1‐arylalkylidene)propanedinitriles 1 and fluoroaryl substituted aromatic amines under Gewald reaction condition, which on reaction with formamide and formic acid gave 4‐aminopyrrolo[2,3‐d]pyrimidines 3 and pyrrolo[2,3‐d]‐pyrimidin‐4(3__H__)‐ones 4 respectively. 4‐Chloropyrrolo[2,3‐d]pyrimidines 5 were prepared by chlorination of 4 with phosphorus oxychloride, which on hydrazinolysis provided 4‐hydrazinopyrrolo[2–3‐d]pyrirnidines 6.

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