## Facile Synthesis of 6-Aryl-1,3-dimethyl-5H-pyrimido[4,5b][1,4]diazepine-2,4(1H,3H)-diones. -A new approach to the regioselective synthesis of the title compounds (IV) starting from readily accessible 6-amino-5-benzylideneaminopyrimidines (I) is described. Condensation of compound (I) with diet
Facile preparation of 9-H-pyrimido [4,5-b] [1,4] diazepine derivatives from 4,5-diaminopyrimidines and ethyl pyruvate.
✍ Scribed by Manuel Melguizo; Adolfo Sánchez; Manuel Nogueras; John N. Low; R. Alan Howie; Graciela Andrei; Erik De Clercq
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- French
- Weight
- 745 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0040-4020
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✦ Synopsis
B-3000 Leuven (E3elgium
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## Abstract magnified image A series of tricyclic 7,8,10,11‐tetrahydro‐5__H__‐benzo[__e__]pyrimido[4,5‐__b__][1,4]diazepin‐9(6__H__)‐ones were prepared in moderate to high yields using TFA‐promoted iminium‐cyclization reactions of 3‐(6‐(butylamino)‐4‐chloropyrimidin‐5‐ylamino)cyclohex‐2‐enones and
## Abstract The novel title heterocyclic scaffold is prepared efficiently from N‐substituted pyrimidinediamines and aldehydes.
## Abstract The reaction of 1‐aryl‐3‐(dimethylamino)‐1‐propanones 1 with one equivalent of 4,5‐diamino‐1__H__‐pyrimidin‐6‐ones 2, in acidic medium, leads to the formation of 4‐aryl‐2,3,6,7‐tetrahydro‐1__H__‐pyrimido[4,5‐__b__]‐[1,4]diazepin‐6‐ones 3. The structure elucidation of the products is bas