𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of 4-aryl-2,3,6,7-tetrahydro-1H-pyrimido[4,5-b][1,4]-diazepin-6-ones from 4,5-diamino-1H-pyrimidin-6-ones and 1-aryl-3-(dimethylamino)-1-propanones

✍ Scribed by Braulio Insuasty; Jairo Quiroga; Juan Carlos Argoti; Samuel Gómez; Roberto Martínez; Enrique Angeles; Rubén Gabiño; Manuel Nogueras; Adolfo Sánchez

Publisher
Journal of Heterocyclic Chemistry
Year
1998
Tongue
English
Weight
202 KB
Volume
35
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The reaction of 1‐aryl‐3‐(dimethylamino)‐1‐propanones 1 with one equivalent of 4,5‐diamino‐1__H__‐pyrimidin‐6‐ones 2, in acidic medium, leads to the formation of 4‐aryl‐2,3,6,7‐tetrahydro‐1__H__‐pyrimido[4,5‐b]‐[1,4]diazepin‐6‐ones 3. The structure elucidation of the products is based on detail nmr analysis of experiments such as ^13^C, ^1^H and DEPT including selective ^13^C{^1^H} decoupling experiments.

📜 SIMILAR VOLUMES

ChemInform Abstract: Facile Synthesis of
ChemInform Abstract: Facile Synthesis of 6-Aryl-1,3-dimethyl-5H-pyrimido[4,5-b][1,4]diazepine-2,4(1H,3H)-diones.
✍ Shahriyar Taghavi-Moghadam; Ruediger Stumpf; Helmut Fischer; Wolfgang Pfleiderer 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 1 views

## Facile Synthesis of 6-Aryl-1,3-dimethyl-5H-pyrimido[4,5b][1,4]diazepine-2,4(1H,3H)-diones. -A new approach to the regioselective synthesis of the title compounds (IV) starting from readily accessible 6-amino-5-benzylideneaminopyrimidines (I) is described. Condensation of compound (I) with diet