Preparation of Substituted Pyrimido[4,5-b]-1,4-benzoxazepines, Thiazepines, and Diazepines via a Pictet—Spengler Cyclization.
✍ Scribed by Matthew A. J. Duncton; Leon M. II Smith; Sabina Burdzovic-Wizeman; Aaron Burns; Hu Liu; Yunyu Mao; Wai C. Wong; Alexander S. Kiselyov
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 38 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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## Abstract An improved and simple method for the preparation of pyrazolo[3,4‐__b__][1,5]benzoxazepine, ‐benzothiazepine and ‐benzodiazepine derivatives was established by the reaction of 5‐chloro‐1‐phenylpyrazole‐4‐carbaldehydes, ethyl 3‐(5‐chloro‐1,3‐diphenylpyrazol‐4‐yl)‐2‐cyanoacrylate and 1,4‐