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Synthesis of novel tricyclic 4-chloro-7,8,10,11-tetrahydro-5H-benzo[e]pyrimido[4,5-b][1,4]diazepin-9(6H)-ones

✍ Scribed by Jinbao Xiang; Lianyou Zheng; Tong Zhu; Qun Dang; Xu Bai

Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
126 KB
Volume
47
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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A series of tricyclic 7,8,10,11‐tetrahydro‐5__H__‐benzo[e]pyrimido[4,5‐b][1,4]diazepin‐9(6__H__)‐ones were prepared in moderate to high yields using TFA‐promoted iminium‐cyclization reactions of 3‐(6‐(butylamino)‐4‐chloropyrimidin‐5‐ylamino)cyclohex‐2‐enones and various aldehydes. J. Heterocyclic Chem., (2010).

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