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Synthesis of novel 6,7-dihydro-5H-pyrimido[4,5-e][1,4]diazepin-8(9H)-ones

✍ Scribed by Jinbao Xiang; Xiaowei Hu; Qun Dang; Xu Bai

Publisher
Journal of Heterocyclic Chemistry
Year
2011
Tongue
English
Weight
84 KB
Volume
48
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

A new method was developed for the synthesis of 6,7‐dihydro‐5__H__‐pyrimido[4,5‐e][1,4]diazepin‐8(9__H__)‐one derivatives. The key to construct the pyrimido[4,5‐e][1,4]diazepine core is the intramolecular amidation of N‐((4‐amino‐6‐chloropyrimidin‐5‐yl)methyl)‐substituted amino acid esters. This methodology was validated through the preparation of 13 representative 6,7‐dihydro‐5__H__‐pyrimido[4,5‐e][1,4]diazepin‐8(9__H__)‐ones in moderate to good yields. J. Heterocyclic Chem., (2011).

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Synthesis of novel tricyclic 4-chloro-7,8,10,11-tetrahydro-5H-benzo[e]pyrimido[4,5-b][1,4]diazepin-9(6H)-ones
✍ Jinbao Xiang; Lianyou Zheng; Tong Zhu; Qun Dang; Xu Bai 📂 Article 📅 2010 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 126 KB

## Abstract magnified image A series of tricyclic 7,8,10,11‐tetrahydro‐5__H__‐benzo[__e__]pyrimido[4,5‐__b__][1,4]diazepin‐9(6__H__)‐ones were prepared in moderate to high yields using TFA‐promoted iminium‐cyclization reactions of 3‐(6‐(butylamino)‐4‐chloropyrimidin‐5‐ylamino)cyclohex‐2‐enones and