✦ LIBER ✦

Synthesis of 4-aryl-4,7,8,9-tetrahydro-6H-pyrazolo[3,4-b]quinolin-5-ones

✍ Scribed by Jairo Quiroga; Braulio Insuasty; Angelina Hormaza; Claudio Saitz; Carolina Jullian

Publisher: Journal of Heterocyclic Chemistry
Year: 1998
Tongue: English
Weight: 215 KB
Volume: 35
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570350313

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Reaction of 5‐amino‐3‐methyl‐1‐phenylpyrazole (1a) and 5‐amino‐3‐(4‐chlorophenyl)‐1__H__‐pyrazole (1b) with dimedone (2) and p‐susbstituted benzaldehydes 3 in ethanol, afforded in all cases tricyclic linear 4‐aryl‐7,7‐dimethyl‐4,7,8,9‐tetrahydro‐6__H__‐pyrazolo[3,4‐b]quinolin‐5‐ones (4a‐j) in good yields. The linear structures and hence the regiospecificity of the reaction were established by nmr measurements.

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