✦ LIBER ✦

Microwave-induced Stereoselectivity in Synthesis of trans-4-Aryl-3-methyl-6-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridine-5-carbonitriles

✍ Scribed by Abbas Rahmati; Meysam Alizadeh Kouzehrash

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 465 KB
Volume: 29
Category: Article
ISSN: 0256-7660
DOI: 10.1002/cjoc.201180405

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✦ Synopsis

Abstract

A facile synthesis of trans isomers of 4‐aryl‐3‐methyl‐6‐oxo‐4,5,6,7‐tetrahydro**‐2__H__‐**pyrazolo[3,4‐b]pyridine‐5‐carbonitriles via three‐component condensation reaction of an aldehyde, 3‐amino‐5‐methylpyrazole and ethyl cyanoacetate in acetonitrile has been developed under microwave irradiation. This one‐pot reaction proceeds without any catalyst in short times and gives the product in high selectivities and high yields.

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