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ChemInform Abstract: Synthesis of 4-Aryl-3-methyl-6-oxo-4,5,6,7-tetrahydro-2H-pyrazolo [3,4-b]pyridine-5-carbonitrile via a One-Pot, Three-Component Reaction.

✍ Scribed by Abbas Rahmati

Publisher
John Wiley and Sons
Year
2010
Weight
27 KB
Volume
41
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

3‐Amino‐5‐methylpyrazole, ethyl cyanoacetate and aromatic aldehydes undergo an acid‐catalyzed condensation to generate diastereomeric mixtures of pyrazolopyridinones (III)/(IV).

📜 SIMILAR VOLUMES

Microwave-induced Stereoselectivity in S
Microwave-induced Stereoselectivity in Synthesis of trans-4-Aryl-3-methyl-6-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridine-5-carbonitriles
✍ Abbas Rahmati; Meysam Alizadeh Kouzehrash 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 465 KB

## Abstract A facile synthesis of __trans__ isomers of 4‐aryl‐3‐methyl‐6‐oxo‐4,5,6,7‐tetrahydro**‐**2__H__**‐**pyrazolo[3,4‐__b__]pyridine‐5‐carbonitriles via three‐component condensation reaction of an aldehyde, 3‐amino‐5‐methylpyrazole and ethyl cyanoacetate in acetonitrile has been developed und