## Abstract A facile synthesis of __trans__ isomers of 4‐aryl‐3‐methyl‐6‐oxo‐4,5,6,7‐tetrahydro**‐**2__H__**‐**pyrazolo[3,4‐__b__]pyridine‐5‐carbonitriles via three‐component condensation reaction of an aldehyde, 3‐amino‐5‐methylpyrazole and ethyl cyanoacetate in acetonitrile has been developed und
✦ LIBER ✦
ChemInform Abstract: Microwave-Induced Stereoselectivity in Synthesis of trans-4-Aryl-3-methyl-6-oxo-4,5,6,7-tetrahydro-2H-pyrazolo [3,4-b]pyridine-5-carbonitriles.
✍ Scribed by Abbas Rahmati; Meysam Alizadeh Kouzehrash
- Publisher
- John Wiley and Sons
- Year
- 2012
- Weight
- 24 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
All products are purified by recrystallization from ethanol.
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## Abstract 3‐Amino‐5‐methylpyrazole, ethyl cyanoacetate and aromatic aldehydes undergo an acid‐catalyzed condensation to generate diastereomeric mixtures of pyrazolopyridinones (III)/(IV).
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