Activity of 06-methylguanine-DNA methyltransferase (MGMT) is well related with drug resistance of tumor cells to chloroethylnitrosoureas (CENUs), because MGMT removes CENU-induced O6-alkyIguanines in DNA by accepting the alkyl group at a cysteine moiety. Inactivation of MGMT is a feasible way to ove
✦ LIBER ✦
Expression of O6-methylguanine-DNA methyltransferase in childhood medulloblastoma
✍ Scribed by Denis Faoro; André O. von Bueren; Tarek Shalaby; Davide Sciuscio; Marie-Louise Hürlimann; Lucia Arnold; Nicolas U. Gerber; Johannes Haybaeck; Michel Mittelbronn; Stefan Rutkowski; Monika Hegi; Michael A. Grotzer
- Book ID
- 106481736
- Publisher
- Springer US
- Year
- 2010
- Tongue
- English
- Weight
- 440 KB
- Volume
- 103
- Category
- Article
- ISSN
- 0167-594X
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