O6-methylguanine-DNA methyltransferase activity in breast and brain tumors
โ Scribed by Ilka Preuss; Ingrid Eberhagen; Simone Haas; Robert H. Eibl; Manfred Kaufmann; Gunther Von Minckwitz; Bernd Kaina
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- French
- Weight
- 787 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0020-7136
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๐ SIMILAR VOLUMES
Activity of 06-methylguanine-DNA methyltransferase (MGMT) is well related with drug resistance of tumor cells to chloroethylnitrosoureas (CENUs), because MGMT removes CENU-induced O6-alkyIguanines in DNA by accepting the alkyl group at a cysteine moiety. Inactivation of MGMT is a feasible way to ove
The DNA repair protein O 6 -methylguanine-DNA methyltransferase (MGMT) is a main determinant of resistance of cells to the cytostatic effects of O 6 -alkylguanine-generating alkylating agents. The purpose of our study was to assay MGMT activity in cells of lung cancers and to correlate MGMT levels w
## Abstract The DNA repair protein __O__^6^โmethylguanineโDNA methyltransferase (MGMT) has been implicated in resistance of human brain tumors to alkylating agents. We observed that 14 human medulloblastomaโ and gliomaderived cell lines differ in sensitivity to the methylating agent __N__โmethylโ__
## Abstract The DNA repair enzyme O^6^โmethylguanineโDNA methyltransferase (MGMT) removes alkylating adducts from the O^6^ position of guanine and protects cells from cytotoxic and mutagenic effects. Expression of __MGMT__ is decreased in some cancers, which may be the result of methylation of CpG