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Influence of O6-methylguanine-DNA methyltransferase activity on chloroethylnitrosourea chemotherapy in brain tumors

✍ Scribed by Katsuyoshi Mineura; Ichiro Izumi; Katsuo Watanabe; Masayoshi Kowada

Publisher: John Wiley and Sons
Year: 1993
Tongue: French
Weight: 729 KB
Volume: 55
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910550115

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Abbreviations: MGMT, 06-methylguanine-DNA methyltransferase, also designated as 06-alkylguanine-DNA alkyltransferase (EC 2.1.1.63); CNUs, chloroethylnitrosoureas; ACNU, 1-(2-chloroethyl)-3-[(4-amino-2-methyl-5-pyrimidyl)-methyl]-l-nitrosourea; BCNU, 1,3-bis-(2-chloroethyl)-1-nitrosourea; CCNU, l-(2-